| Date | Time | Opponent | Score | |
| Fri, 9/3/2010 | 7:00 PM | vs Whitehall | 13 - 35 | Loss |
| Fri, 9/10/2010 | 7:00 PM | vs Exeter | 28 - 6 | Win |
| Fri, 9/17/2010 | 7:00 PM | at Pottsville | 28 - 45 | Loss |
| Fri, 9/24/2010 | 7:00 PM | at Hamburg | 47 - 7 | Win |
| Fri, 10/1/2010 | 7:00 PM | vs Schuylkill Valley | 42 - 14 | Win |
| Fri, 10/8/2010 | 7:00 PM | at Kutztown | 50 - 15 | Win |
| Fri, 10/15/2010 | 7:00 PM | vs Fleetwood | 56 - 21 | Win |
| Fri, 10/22/2010 | 7:00 PM | vs Central Catholic | 51 - 7 | Win |
| Fri, 10/29/2010 | 7:00 PM | at Holy Name | 14 - 20 | Loss |
| Sat, 11/6/2010 | 1:30 PM | at Wyomissing | 42 - 20 | Win |
| Fri, 11/12/2010 | 7:00 PM | at Allentown Central Catholic | 20 - 55 | Loss |