| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | vs Whitehall | L 13-35 |
| Fri, 9/10/2010 | 7:00 PM | vs Exeter | W 28-6 |
| Fri, 9/17/2010 | 7:00 PM | at Pottsville | L 45-28 |
| Fri, 9/24/2010 | 7:00 PM | at Hamburg | W 7-47 |
| Fri, 10/1/2010 | 7:00 PM | vs Schuylkill Valley | W 42-14 |
| Fri, 10/8/2010 | 7:00 PM | at Kutztown | W 15-50 |
| Fri, 10/15/2010 | 7:00 PM | vs Fleetwood | W 56-21 |
| Fri, 10/22/2010 | 7:00 PM | vs Central Catholic | W 51-7 |
| Fri, 10/29/2010 | 7:00 PM | at Holy Name | L 20-14 |
| Sat, 11/6/2010 | 1:30 PM | at Wyomissing | W 20-42 |
| Fri, 11/12/2010 | 7:00 PM | at Allentown Central Catholic | L 55-20 |