| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at Holy Name | L 49-21 |
| Fri, 9/10/2010 | 7:00 PM | at Pottsgrove | L 57-6 |
| Fri, 9/17/2010 | 7:00 PM | at Phoenixville | L 23-0 |
| Sat, 9/25/2010 | 1:00 PM | vs Boyertown | L 13-35 |
| Sat, 10/2/2010 | 1:00 PM | at Perkiomen Valley | L 22-6 |
| Sat, 10/9/2010 | 1:00 PM | vs Pottstown | W 33-32 |
| Fri, 10/15/2010 | 7:00 PM | at Spring-Ford | L 49-0 |
| Sat, 10/23/2010 | 1:00 PM | vs Owen J. Roberts | L 20-42 |
| Sat, 10/30/2010 | 1:00 PM | at Methacton | L 42-21 |
| Sat, 11/6/2010 | 1:00 PM | vs Upper Perkiomen | L 35-49 |
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