| Date | Time | Opponent | Score |
| Sat, 8/28/2021 | 3:00 PM | vs McCaskey | L 20-27 |
| Fri, 9/3/2021 | 7:00 PM | at Lebanon | W 22-42 |
| Fri, 9/10/2021 | 7:00 PM | vs Academy Park | L 6-41 |
| Fri, 9/17/2021 | 7:00 PM | vs Owen J. Roberts | L 6-39 |
| Fri, 10/8/2021 | 7:00 PM | vs Berks Catholic | L 12-42 |
| Fri, 10/15/2021 | 7:00 PM | at Daniel Boone | L 35-0 |
| Fri, 10/22/2021 | 7:00 PM | at Exeter | L 49-6 |
| Fri, 10/29/2021 | 7:00 PM | vs Muhlenberg | L 6-38 |
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