| Date | Time | Opponent | Score |
| Sat, 8/28/2021 | 6:00 PM | at York | W 6-55 |
| Fri, 9/3/2021 | 7:00 PM | vs Wilson | W 42-14 |
| Fri, 9/10/2021 | 7:00 PM | at Cocalico | W 0-56 |
| Fri, 9/17/2021 | 7:00 PM | vs Harrisburg | W 49-13 |
| Fri, 9/24/2021 | 7:00 PM | at Episcopal Academy | W 26-49 |
| Fri, 10/8/2021 | 7:00 PM | at Exeter | W 21-54 |
| Fri, 10/15/2021 | 7:00 PM | vs Muhlenberg | W 49-0 |
| Fri, 10/29/2021 | 7:00 PM | at Berks Catholic | W 13-42 |
| Fri, 11/12/2021 | 7:00 PM | vs Warwick | W 63-35 |
| Fri, 11/19/2021 | 7:00 PM | vs Spring Grove | W 38-13 |
| Fri, 11/26/2021 | 7:00 PM | vs Exeter | L 28-31 |
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