| Date | Time | Opponent | Score |
| Sat, 8/28/2021 | 3:00 PM | at Reading High | W 20-27 |
| Fri, 9/3/2021 | 7:00 PM | vs York | L 7-54 |
| Fri, 9/10/2021 | 7:00 PM | vs Lebanon | W 60-6 |
| Fri, 9/17/2021 | 7:00 PM | at Elizabethtown | L 39-15 |
| Fri, 9/24/2021 | 7:00 PM | at Conestoga Valley | L 35-7 |
| Fri, 10/1/2021 | 7:00 PM | at Hempfield | L 41-6 |
| Fri, 10/8/2021 | 7:00 PM | at Wilson | L 59-12 |
| Fri, 10/15/2021 | 7:00 PM | vs Penn Manor | L 17-21 |
| Fri, 10/22/2021 | 7:00 PM | vs Manheim Township | L 21-62 |
| Fri, 10/29/2021 | 7:00 PM | at Cedar Crest | L 42-0 |
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