| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | vs Berks Catholic | W 15-44 |
| Tue, 9/7/2021 | 4:30 PM | vs Oley Valley | W 16-47 |
| Tue, 9/7/2021 | 4:30 PM | vs Reading High | W 15-50 |
| Tue, 9/14/2021 | 4:30 PM | at Wyomissing | W 33-22 |
| Tue, 9/14/2021 | 4:30 PM | at Twin Valley | L 25-31 |
| Tue, 9/14/2021 | 4:30 PM | vs Conrad Weiser | W 16-43 |
| Tue, 9/21/2021 | 4:30 PM | vs Wilson | W 21-38 |
| Tue, 9/21/2021 | 4:30 PM | at Kutztown | W 47-16 |
| Tue, 9/21/2021 | 4:30 PM | at Schuylkill Valley | W 43-20 |
| Tue, 10/5/2021 | 4:30 PM | at Tulpehocken | L 20-37 |
| Tue, 10/5/2021 | 4:30 PM | at Gov. Mifflin | L 19-36 |
| Tue, 10/5/2021 | 4:30 PM | vs Daniel Boone | W 17-46 |
| Tue, 10/12/2021 | 4:30 PM | at Muhlenberg | W 50-15 |
| Tue, 10/12/2021 | 4:30 PM | at Fleetwood | W 50-15 |
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