| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | at Wyomissing | L 21-40 |
| Tue, 9/7/2021 | 4:30 PM | at Hamburg | W 50-15 |
| Tue, 9/7/2021 | 4:30 PM | at Kutztown | L 23-32 |
| Tue, 9/14/2021 | 4:30 PM | vs Muhlenberg | W 15-50 |
| Tue, 9/14/2021 | 4:30 PM | vs Schuylkill Valley | W 20-42 |
| Tue, 9/14/2021 | 7:00 PM | vs Reading High | W 15-50 |
| Tue, 9/21/2021 | 4:30 PM | vs Berks Catholic | W 27-28 |
| Tue, 9/21/2021 | 4:30 PM | vs Fleetwood | W 24-35 |
| Tue, 9/21/2021 | 4:30 PM | vs Conrad Weiser | W 24-34 |
| Tue, 10/5/2021 | 4:30 PM | at Exeter | L 17-46 |
| Tue, 10/5/2021 | 4:30 PM | at Gov. Mifflin | L 15-48 |
| Tue, 10/5/2021 | 4:30 PM | at Tulpehocken | L 20-36 |
| Tue, 10/12/2021 | 4:30 PM | at Oley Valley | W 38-21 |
| Tue, 10/12/2021 | 4:30 PM | at Twin Valley | L 19-42 |
| Tue, 10/12/2021 | 4:30 PM | at Wilson | L 20-37 |
|