| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | at Wilson | L 15-50 |
| Tue, 9/7/2021 | 4:30 PM | vs Conrad Weiser | L 45-17 |
| Tue, 9/7/2021 | 4:30 PM | at Tulpehocken | L 17-44 |
| Tue, 9/14/2021 | 4:30 PM | at Schuylkill Valley | L 15-50 |
| Tue, 9/14/2021 | 4:30 PM | at Daniel Boone | L 15-50 |
| Tue, 9/21/2021 | 4:30 PM | at Wyomissing | L 15-50 |
| Tue, 9/21/2021 | 4:30 PM | at Oley Valley | L 20-38 |
| Tue, 9/21/2021 | 4:30 PM | vs Gov. Mifflin | L 50-15 |
| Tue, 10/5/2021 | 4:30 PM | vs Kutztown | L 46-15 |
| Tue, 10/5/2021 | 4:30 PM | vs Twin Valley | L 50-15 |
| Tue, 10/5/2021 | 4:30 PM | vs Berks Catholic | L 44-17 |
| Tue, 10/12/2021 | 4:30 PM | vs Exeter | L 50-15 |
| Tue, 10/12/2021 | 4:30 PM | at Fleetwood | L 22-35 |
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