| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | at Wilson | L 21-38 |
| Tue, 9/7/2021 | 4:30 PM | at Muhlenberg | W 45-17 |
| Tue, 9/7/2021 | 4:30 PM | at Tulpehocken | L 23-34 |
| Tue, 9/14/2021 | 4:30 PM | at Exeter | L 16-43 |
| Tue, 9/14/2021 | 4:30 PM | at Wyomissing | L 23-36 |
| Tue, 9/14/2021 | 4:30 PM | at Twin Valley | L 17-46 |
| Tue, 9/21/2021 | 4:30 PM | at Daniel Boone | L 24-34 |
| Tue, 9/21/2021 | 4:30 PM | at Berks Catholic | W 29-27 |
| Tue, 9/21/2021 | 4:30 PM | at Fleetwood | W 35-21 |
| Tue, 10/5/2021 | 4:30 PM | at Oley Valley | W 27-22 |
| Tue, 10/5/2021 | 4:30 PM | at Schuylkill Valley | W 35-22 |
| Tue, 10/5/2021 | 4:30 PM | at Hamburg | W 50-15 |
| Tue, 10/12/2021 | 4:30 PM | at Gov. Mifflin | L 19-43 |
| Tue, 10/12/2021 | 4:30 PM | at Kutztown | L 25-31 |
| Tue, 10/12/2021 | 7:00 PM | at Reading High | W 44-17 |
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