| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | vs Daniel Boone | W 23-32 |
| Tue, 9/7/2021 | 4:30 PM | vs Hamburg | W 15-50 |
| Tue, 9/7/2021 | 4:30 PM | at Wyomissing | L 20-38 |
| Tue, 9/14/2021 | 4:30 PM | at Oley Valley | W 38-19 |
| Tue, 9/14/2021 | 4:30 PM | at Tulpehocken | L 21-34 |
| Tue, 9/14/2021 | 4:30 PM | vs Fleetwood | W 21-34 |
| Tue, 9/21/2021 | 4:30 PM | vs Exeter | L 47-16 |
| Tue, 9/21/2021 | 4:30 PM | vs Wilson | L 33-22 |
| Tue, 9/21/2021 | 4:30 PM | vs Schuylkill Valley | W 20-40 |
| Tue, 10/5/2021 | 4:30 PM | at Muhlenberg | W 46-15 |
| Tue, 10/5/2021 | 4:30 PM | at Twin Valley | L 18-42 |
| Tue, 10/5/2021 | 7:00 PM | vs Berks Catholic | W 23-32 |
| Tue, 10/12/2021 | 4:30 PM | vs Conrad Weiser | W 25-31 |
| Tue, 10/12/2021 | 4:30 PM | vs Gov. Mifflin | L 42-20 |
| Tue, 10/12/2021 | 4:30 PM | vs Reading High | W 15-48 |
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