| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | at Wilson | L 23-36 |
| Tue, 9/7/2021 | 4:30 PM | vs Conrad Weiser | W 23-34 |
| Tue, 9/7/2021 | 4:30 PM | vs Muhlenberg | W 17-44 |
| Tue, 9/14/2021 | 4:30 PM | vs Oley Valley | W 19-43 |
| Tue, 9/14/2021 | 4:30 PM | vs Kutztown | W 21-34 |
| Tue, 9/14/2021 | 4:30 PM | vs Fleetwood | W 17-43 |
| Tue, 9/21/2021 | 4:30 PM | vs Twin Valley | L 46-17 |
| Tue, 9/21/2021 | 4:30 PM | vs Hamburg | W 15-50 |
| Tue, 9/21/2021 | 4:30 PM | at Reading High | W 50-15 |
| Tue, 10/5/2021 | 4:30 PM | vs Exeter | W 20-37 |
| Tue, 10/5/2021 | 4:30 PM | at Gov. Mifflin | L 19-42 |
| Tue, 10/5/2021 | 4:30 PM | vs Daniel Boone | W 20-36 |
| Wed, 10/13/2021 | 4:30 PM | at Berks Catholic | W 36-19 |
| Wed, 10/13/2021 | 4:30 PM | vs Schuylkill Valley | W 20-39 |
| Wed, 10/13/2021 | 4:30 PM | vs Wyomissing | W 21-34 |
|