| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | vs Twin Valley | L 43-20 |
| Tue, 9/7/2021 | 4:30 PM | vs Fleetwood | L 39-22 |
| Tue, 9/7/2021 | 4:30 PM | vs Gov. Mifflin | L 43-20 |
| Tue, 9/14/2021 | 4:30 PM | at Daniel Boone | L 20-42 |
| Tue, 9/14/2021 | 4:30 PM | vs Muhlenberg | W 15-50 |
| Tue, 9/14/2021 | 4:30 PM | vs Reading High | W 15-50 |
| Tue, 9/21/2021 | 4:30 PM | at Wilson | L 20-43 |
| Tue, 9/21/2021 | 4:30 PM | vs Exeter | L 43-20 |
| Tue, 9/21/2021 | 4:30 PM | at Kutztown | L 20-40 |
| Tue, 10/5/2021 | 4:30 PM | at Hamburg | W 50-15 |
| Tue, 10/5/2021 | 4:30 PM | vs Conrad Weiser | L 35-22 |
| Tue, 10/5/2021 | 4:30 PM | vs Oley Valley | W 26-29 |
| Wed, 10/13/2021 | 4:30 PM | at Tulpehocken | L 20-39 |
| Wed, 10/13/2021 | 4:30 PM | vs Wyomissing | L 43-20 |
| Wed, 10/13/2021 | 4:30 PM | at Berks Catholic | L 21-38 |
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