| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 4:30 PM | at Schuylkill Valley | W 39-22 |
| Tue, 9/7/2021 | 4:30 PM | at Gov. Mifflin | L 15-50 |
| Tue, 9/7/2021 | 4:30 PM | vs Twin Valley | L 50-15 |
| Tue, 9/14/2021 | 4:30 PM | at Kutztown | L 21-34 |
| Tue, 9/14/2021 | 4:30 PM | at Oley Valley | W 34-22 |
| Tue, 9/14/2021 | 4:30 PM | at Tulpehocken | L 17-43 |
| Tue, 9/21/2021 | 4:30 PM | vs Conrad Weiser | L 35-21 |
| Tue, 9/21/2021 | 4:30 PM | at Daniel Boone | L 24-35 |
| Tue, 9/21/2021 | 4:30 PM | vs Berks Catholic | L 35-24 |
| Tue, 10/5/2021 | 4:30 PM | vs Wilson | L 34-23 |
| Tue, 10/5/2021 | 4:30 PM | vs Reading High | W 15-50 |
| Tue, 10/5/2021 | 4:30 PM | at Wyomissing | L 18-45 |
| Tue, 10/12/2021 | 4:30 PM | vs Muhlenberg | W 22-35 |
| Tue, 10/12/2021 | 4:30 PM | vs Exeter | L 50-15 |
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