| Date | Time | Opponent | Score |
| Sat, 9/4/2021 | 7:00 PM | vs La Salle College | L 9-11 |
| Sat, 9/4/2021 | 7:00 PM | at Perkiomen Valley | W 5-15 |
| Sat, 9/4/2021 | 7:00 PM | at Exeter | W 2-10 |
| Sat, 9/4/2021 | 7:00 PM | at Wissahickon | W 16-18 |
| Thu, 9/9/2021 | 4:30 PM | at Hazleton | W 8-13 |
| Tue, 9/14/2021 | 4:30 PM | vs Mechanicsburg | W 12-3 |
| Sat, 9/18/2021 | 7:00 PM | at Pennridge | W 4-13 |
| Sat, 9/18/2021 | 7:00 PM | at La Salle | W 11-14 |
| Sat, 9/18/2021 | 7:00 PM | at North Penn (Lansdale) | L 6-5 |
| Mon, 9/20/2021 | 6:00 PM | at Reading High | W 11-15 |
| Wed, 9/22/2021 | 4:30 PM | vs Cumberland Valley | W 20-11 |
| Fri, 9/24/2021 | 4:00 PM | vs The Hill School | W 17-8 |
| Fri, 9/24/2021 | 7:00 PM | vs Brunswick | L 9-19 |
| Sat, 9/25/2021 | 7:00 PM | at La Salle | W 5-13 |
| Sat, 9/25/2021 | 7:00 PM | vs Greenwich (Conn.) | L 11-20 |
| Wed, 9/29/2021 | 5:30 PM | at Gov. Mifflin | L 18-15 |
| Wed, 10/6/2021 | 5:00 PM | vs Muhlenberg | W 14-7 |
| Wed, 10/13/2021 | 5:00 PM | vs Gov. Mifflin | W 14-7 |
| Fri, 10/15/2021 | 5:00 PM | at Erie Cathedral Prep | W 7-15 |
| Sat, 10/16/2021 | 7:00 PM | at Erie McDowell | W 7-17 |
| Sat, 10/16/2021 | 7:00 PM | at North Allegheny | L 8-7 |
| Wed, 10/20/2021 | 4:30 PM | at Cumberland Valley | L 11-9 |
| Fri, 11/5/2021 | 8:00 PM | vs Gov. Mifflin | L 16-17 |
| Sat, 11/6/2021 | 9:00 AM | at Cathedral Prep | W 5-13 |
| Sat, 11/6/2021 | 7:00 PM | at Hazelton | W 12-19 |
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