| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 5:00 PM | at Tulpehocken | W 36-20 |
| Tue, 9/7/2021 | 5:00 PM | at Wilson | L 21-36 |
| Tue, 9/7/2021 | 7:00 PM | at Muhlenberg | W 50-15 |
| Tue, 9/14/2021 | 5:00 PM | at Exeter | L 22-35 |
| Tue, 9/14/2021 | 5:00 PM | at Wyomissing | W 30-25 |
| Tue, 9/14/2021 | 5:00 PM | at Twin Valley | W 33-24 |
| Tue, 9/21/2021 | 5:00 PM | at Daniel Boone | W 30-26 |
| Tue, 9/21/2021 | 5:00 PM | at Fleetwood | W 46-16 |
| Tue, 9/21/2021 | 5:00 PM | vs Berks Catholic | W 27-28 |
| Tue, 10/5/2021 | 5:00 PM | at Schuylkill Valley | W 46-15 |
| Tue, 10/5/2021 | 5:00 PM | at Oley Valley | W 38-21 |
| Tue, 10/5/2021 | 5:00 PM | at Hamburg | W 49-15 |
| Tue, 10/12/2021 | 5:00 PM | at Gov. Mifflin | L 20-41 |
| Tue, 10/12/2021 | 5:00 PM | at Reading High | W 49-15 |
| Tue, 10/12/2021 | 7:00 PM | at Kutztown | W 44-17 |
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