| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 5:00 PM | at Schuylkill Valley | L 25-35 |
| Tue, 9/7/2021 | 5:00 PM | at Gov. Mifflin | L 15-50 |
| Tue, 9/7/2021 | 5:00 PM | at Twin Valley | L 18-43 |
| Tue, 9/14/2021 | 5:00 PM | at Kutztown | W 32-25 |
| Tue, 9/14/2021 | 5:00 PM | at Oley Valley | W 31-28 |
| Tue, 9/14/2021 | 5:00 PM | at Tulpehocken | W 50-15 |
| Tue, 9/21/2021 | 5:00 PM | vs Berks Catholic | L 47-15 |
| Tue, 9/21/2021 | 5:00 PM | vs Conrad Weiser | L 46-16 |
| Tue, 9/21/2021 | 5:00 PM | vs Daniel Boone | L 49-16 |
| Tue, 10/5/2021 | 5:00 PM | vs Wilson | L 50-15 |
| Tue, 10/5/2021 | 5:00 PM | at Wyomissing | L 15-49 |
| Tue, 10/5/2021 | 7:00 PM | at Reading High | W 50-15 |
| Tue, 10/12/2021 | 5:00 PM | vs Exeter | L 50-15 |
| Tue, 10/12/2021 | 5:00 PM | vs Hamburg | W 21-34 |
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