| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 5:00 PM | vs Daniel Boone | W 19-40 |
| Tue, 9/7/2021 | 5:00 PM | at Hamburg | W 50-15 |
| Tue, 9/7/2021 | 5:00 PM | vs Kutztown | W 15-50 |
| Tue, 9/14/2021 | 5:00 PM | vs Exeter | L 41-17 |
| Tue, 9/14/2021 | 5:00 PM | vs Conrad Weiser | L 30-25 |
| Tue, 9/14/2021 | 5:00 PM | at Twin Valley | W 33-24 |
| Tue, 9/21/2021 | 5:00 PM | vs Gov. Mifflin | L 46-15 |
| Tue, 9/21/2021 | 5:00 PM | at Oley Valley | W 36-25 |
| Tue, 10/5/2021 | 5:00 PM | vs Reading High | W 15-50 |
| Tue, 10/5/2021 | 5:00 PM | vs Fleetwood | W 15-49 |
| Tue, 10/5/2021 | 5:00 PM | vs Wilson | L 34-23 |
| Wed, 10/13/2021 | 5:00 PM | at Berks Catholic | L 21-34 |
| Wed, 10/13/2021 | 5:00 PM | at Schuylkill Valley | W 48-15 |
| Wed, 10/13/2021 | 5:00 PM | at Tulpehocken | W 50-15 |
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