| Date | Time | Opponent | Score |
| Tue, 9/7/2021 | 5:00 PM | vs Conrad Weiser | W 21-36 |
| Tue, 9/7/2021 | 5:00 PM | vs Tulpehocken | W 16-44 |
| Tue, 9/7/2021 | 7:00 PM | vs Muhlenberg | W 15-50 |
| Tue, 9/14/2021 | 5:00 PM | vs Berks Catholic | W 17-40 |
| Tue, 9/14/2021 | 5:00 PM | vs Gov. Mifflin | L 29-28 |
| Tue, 9/14/2021 | 5:00 PM | vs Hamburg | W 15-50 |
| Tue, 9/21/2021 | 5:00 PM | at Kutztown | W 47-16 |
| Tue, 9/21/2021 | 5:00 PM | at Exeter | L 28-30 |
| Tue, 9/21/2021 | 7:00 PM | at Schuylkill Valley | W 50-15 |
| Tue, 10/5/2021 | 5:00 PM | at Fleetwood | W 50-15 |
| Tue, 10/5/2021 | 5:00 PM | at Reading High | W 50-15 |
| Tue, 10/5/2021 | 5:00 PM | at Wyomissing | W 34-23 |
| Tue, 10/12/2021 | 5:00 PM | at Oley Valley | W 50-15 |
| Tue, 10/12/2021 | 5:00 PM | at Twin Valley | W 47-16 |
| Tue, 10/12/2021 | 5:00 PM | vs Daniel Boone | W 23-33 |
|