| Date | Time | Opponent | Score |
| Fri, 8/26/2022 | 7:00 PM | at West Chester East | W 7-56 |
| Fri, 9/2/2022 | 7:00 PM | vs Immaculata | W 44-43 |
| Fri, 9/9/2022 | 7:00 PM | vs Cocalico | W 35-19 |
| Fri, 9/16/2022 | 7:00 PM | vs Susquehannock | W 49-0 |
| Fri, 9/23/2022 | 7:00 PM | vs Warwick | W 47-13 |
| Fri, 9/30/2022 | 7:00 PM | vs Muhlenberg | W 70-0 |
| Fri, 10/7/2022 | 7:00 PM | at Lebanon | W 7-83 |
| Fri, 10/14/2022 | 7:00 PM | vs Conestoga Valley | W 48-0 |
| Fri, 10/21/2022 | 7:00 PM | at Gov. Mifflin | W 21-69 |
| Fri, 10/28/2022 | 7:00 PM | vs Exeter | L 17-21 |
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