| Date | Time | Opponent | Score |
| Fri, 8/26/2022 | 7:00 PM | vs Muhlenberg | L 13-25 |
| Fri, 9/2/2022 | 7:00 PM | at Pequea Valley | W 0-35 |
| Fri, 9/9/2022 | 7:00 PM | at Lancaster Catholic | L 41-7 |
| Fri, 9/16/2022 | 7:00 PM | at Cocalico | L 56-6 |
| Fri, 9/23/2022 | 7:00 PM | vs Conrad Weiser | L 7-45 |
| Fri, 9/30/2022 | 7:00 PM | vs Lampeter-Strasburg | L 13-49 |
| Fri, 10/7/2022 | 7:00 PM | at Elco | L 41-21 |
| Fri, 10/14/2022 | 7:00 PM | vs Berks Catholic | L 7-38 |
| Fri, 10/21/2022 | 7:00 PM | vs Wyomissing | L 7-56 |
| Fri, 10/28/2022 | 7:00 PM | at Donegal | L 37-6 |
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