| Date | Time | Opponent | Score |
| Sat, 8/27/2022 | 1:30 PM | vs Kennard-Dale | W 49-0 |
| Fri, 9/2/2022 | 7:00 PM | at Pottsville | W 0-49 |
| Sat, 9/10/2022 | 1:30 PM | vs Trinity | W 35-14 |
| Fri, 9/16/2022 | 7:00 PM | at Berks Catholic | W 24-41 |
| Fri, 9/23/2022 | 7:00 PM | at Elco | W 0-42 |
| Fri, 9/30/2022 | 7:00 PM | at Donegal | W 7-41 |
| Sat, 10/8/2022 | 1:30 PM | vs Cocalico | W 38-7 |
| Fri, 10/14/2022 | 7:00 PM | at Conrad Weiser | W 10-49 |
| Fri, 10/21/2022 | 7:00 PM | at Octorara | W 7-56 |
| Sat, 10/29/2022 | 1:30 PM | vs Lampeter-Strasburg | W 21-0 |
| Sat, 11/12/2022 | 1:00 PM | vs Hamburg | W 49-14 |
| Sat, 11/19/2022 | 7:00 PM | vs West Perry | W 63-7 |
| Sat, 11/26/2022 | 7:00 PM | at Danville | W 19-21 |
| Sat, 12/3/2022 | 1:00 PM | vs Neumann-Goretti | L 17-20 |
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