| Date | Time | Opponent | Score |
| Fri, 8/26/2022 | 7:00 PM | at Cumberland Valley | L 31-27 |
| Fri, 9/2/2022 | 7:00 PM | vs Dallastown | W 40-0 |
| Sat, 9/10/2022 | 1:00 PM | at Harrisburg | W 20-24 |
| Fri, 9/16/2022 | 7:00 PM | at Spring-Ford | W 14-17 |
| Fri, 9/23/2022 | 7:00 PM | vs Hempfield | L 14-17 |
| Fri, 9/30/2022 | 7:00 PM | vs McCaskey | W 55-6 |
| Fri, 10/7/2022 | 7:00 PM | at Cedar Crest | W 14-42 |
| Fri, 10/14/2022 | 7:00 PM | at Reading High | W 14-49 |
| Fri, 10/21/2022 | 7:00 PM | vs Penn Manor | W 35-13 |
| Fri, 10/28/2022 | 7:00 PM | vs Wilson | L 21-27 |
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