| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at Donegal | W 13-46 |
| Fri, 9/10/2010 | 7:00 PM | vs Susquehannock | W 35-7 |
| Fri, 9/17/2010 | 7:00 PM | at Columbia | W 25-49 |
| Fri, 9/24/2010 | 7:00 PM | at Twin Valley | W 0-41 |
| Fri, 10/1/2010 | 7:00 PM | vs Pottsville | W 16-14 |
| Fri, 10/8/2010 | 7:00 PM | at Reading High | W 33-39 |
| Fri, 10/15/2010 | 7:00 PM | vs Muhlenberg | W 28-21 |
| Fri, 10/22/2010 | 7:00 PM | at Gov. Mifflin | L 42-0 |
| Fri, 10/29/2010 | 7:00 PM | vs Conrad Weiser | W 27-20 |
| Fri, 11/5/2010 | 7:00 PM | vs Exeter | W 21-10 |
| Fri, 11/12/2010 | 7:00 PM | vs Cedar Cliff | W 34-16 |
| Sat, 11/20/2010 | 1:00 PM | at Harrisburg | W 12-14 |
| Fri, 11/26/2010 | 7:00 PM | vs Red Lion | L 0-14 |
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