| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at West Chester East | W 20-45 |
| Fri, 9/10/2010 | 7:00 PM | at Sussex Tech (Del.) | W 7-27 |
| Fri, 9/17/2010 | 7:00 PM | at Owen J. Roberts | W 7-20 |
| Sat, 9/25/2010 | 1:00 PM | at Methacton | L 25-20 |
| Sat, 10/2/2010 | 1:00 PM | vs Upper Perkiomen | W 42-34 |
| Fri, 10/8/2010 | 7:00 PM | at Pottsgrove | L 20-14 |
| Fri, 10/15/2010 | 7:00 PM | vs Pope John Paul II | W 49-0 |
| Fri, 10/22/2010 | 7:00 PM | at Boyertown | L 20-0 |
| Fri, 10/29/2010 | 7:00 PM | vs Perkiomen Valley | W 28-0 |
| Fri, 11/5/2010 | 7:00 PM | at Pottstown | W 21-28 |
| Fri, 11/12/2010 | 7:00 PM | at Upper Darby | W 13-24 |
| Thu, 11/25/2010 | 10:00 AM | vs Phoenixville | W 26-3 |
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