| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | vs Jules E. Mastbaum | W 49-6 |
| Fri, 9/10/2010 | 7:00 PM | vs Pope John Paul II | W 57-6 |
| Fri, 9/17/2010 | 7:00 PM | at Boyertown | L 34-28 |
| Fri, 9/24/2010 | 7:00 PM | vs Perkiomen Valley | W 21-10 |
| Fri, 10/1/2010 | 7:00 PM | at Pottstown | W 10-30 |
| Fri, 10/8/2010 | 7:00 PM | vs Spring-Ford | W 20-14 |
| Fri, 10/15/2010 | 7:00 PM | at Owen J. Roberts | L 49-20 |
| Fri, 10/22/2010 | 7:00 PM | vs Methacton | W 49-0 |
| Fri, 10/29/2010 | 7:00 PM | at Upper Perkiomen | W 19-69 |
| Fri, 11/5/2010 | 7:00 PM | vs Phoenixville | W 42-15 |
| Fri, 11/12/2010 | 7:00 PM | vs Academy Park | W 42-11 |
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