| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at Conestoga | L 36-29 |
| Fri, 9/10/2010 | 7:00 PM | vs Reading High | W 58-6 |
| Fri, 9/17/2010 | 7:00 PM | vs Spring-Ford | L 7-20 |
| Fri, 9/24/2010 | 7:00 PM | vs Phoenixville | W 27-0 |
| Fri, 10/1/2010 | 7:00 PM | vs Methacton | W 42-7 |
| Fri, 10/8/2010 | 7:00 PM | at Upper Perkiomen | W 20-55 |
| Fri, 10/15/2010 | 7:00 PM | vs Pottsgrove | W 49-20 |
| Sat, 10/23/2010 | 1:00 PM | at Pope John Paul II | W 20-42 |
| Fri, 10/29/2010 | 7:00 PM | vs Boyertown | W 55-14 |
| Fri, 11/5/2010 | 7:00 PM | at Perkiomen Valley | W 7-32 |
| Fri, 11/12/2010 | 7:00 PM | at Downingtown East | L 41-7 |
| Thu, 11/25/2010 | 10:00 AM | vs Pottstown | W 49-17 |
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