| Date | Time | Opponent | Score |
| Sat, 9/4/2010 | 1:00 PM | at Pius X | W 20-27 |
| Sat, 9/11/2010 | 7:30 PM | vs Upper Moreland | L 14-26 |
| Fri, 9/17/2010 | 7:00 PM | vs Methacton | L 10-17 |
| Fri, 9/24/2010 | 7:00 PM | at Upper Perkiomen | L 35-6 |
| Fri, 10/1/2010 | 7:00 PM | vs Pottsgrove | L 10-30 |
| Sat, 10/9/2010 | 1:00 PM | at Pope John Paul II | L 33-32 |
| Fri, 10/15/2010 | 7:00 PM | vs Boyertown | L 7-35 |
| Fri, 10/22/2010 | 7:00 PM | at Perkiomen Valley | L 20-17 |
| Sat, 10/30/2010 | 2:00 PM | at Phoenixville | W 7-34 |
| Fri, 11/5/2010 | 7:00 PM | vs Spring-Ford | L 21-28 |
| Fri, 11/12/2010 | 7:00 PM | at William Tennent | W 30-31 |
| Thu, 11/25/2010 | 10:00 AM | at Owen J. Roberts | L 49-17 |
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