| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at Exeter | L 35-7 |
| Fri, 9/10/2010 | 7:00 PM | vs Cocalico | W 21-20 |
| Fri, 9/17/2010 | 7:00 PM | vs Conestoga Valley | W 7-3 |
| Fri, 9/24/2010 | 7:00 PM | vs Manheim Township | L 32-47 |
| Fri, 10/1/2010 | 7:00 PM | at Penn Manor | L 21-0 |
| Fri, 10/8/2010 | 7:00 PM | at Warwick | L 35-28 |
| Fri, 10/15/2010 | 7:00 PM | vs Wilson | L 0-63 |
| Fri, 10/22/2010 | 7:00 PM | at Hempfield | L 44-13 |
| Fri, 10/29/2010 | 7:00 PM | vs Cedar Crest | L 23-28 |
| Fri, 11/5/2010 | 7:00 PM | at McCaskey | L 35-21 |
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