| Date | Time | Opponent | Score |
| Sat, 9/4/2010 | 2:00 PM | vs Peabody | W 47-0 |
| Fri, 9/10/2010 | 7:00 PM | at York | W 14-45 |
| Fri, 9/17/2010 | 7:00 PM | vs Lancaster Catholic | L 7-17 |
| Fri, 9/24/2010 | 7:00 PM | at Wilson | L 34-7 |
| Fri, 10/1/2010 | 7:00 PM | at Hempfield | W 7-27 |
| Fri, 10/8/2010 | 7:00 PM | vs Penn Manor | W 20-14 |
| Fri, 10/15/2010 | 7:00 PM | vs Warwick | L 18-26 |
| Fri, 10/22/2010 | 7:00 PM | at Cedar Crest | W 21-28 |
| Fri, 10/29/2010 | 7:00 PM | at Manheim Township | W 14-17 |
| Fri, 11/5/2010 | 7:00 PM | vs Ephrata | W 35-21 |
| Fri, 11/12/2010 | 7:00 PM | at Red Lion | L 14-13 |
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