| Date | Time | Opponent | Score |
| Fri, 3/25/2022 | 4:15 PM | at Pequea Valley | W 4-16 |
| Tue, 3/29/2022 | 4:15 PM | at Tulpehocken | W 8-10 |
| Wed, 3/30/2022 | 4:00 PM | at Schuylkill Haven | W 2-9 |
| Fri, 4/1/2022 | 4:00 PM | at Gov. Mifflin | L 14-2 |
| Mon, 4/11/2022 | 4:00 PM | at Wyomissing | W 6-8 |
| Wed, 4/13/2022 | 4:00 PM | vs Berks Catholic | L 0-8 |
| Thu, 4/14/2022 | 4:00 PM | vs Hamburg | L 2-18 |
| Wed, 4/20/2022 | 4:00 PM | vs Antietam | W 15-0 |
| Thu, 4/21/2022 | 4:00 PM | vs Fleetwood | L 10-16 |
| Sat, 4/23/2022 | 11:00 AM | vs Conrad Weiser | L 3-15 |
| Mon, 4/25/2022 | 4:00 PM | vs Brandywine Heights | L 1-15 |
| Tue, 4/26/2022 | 4:00 PM | at Schuylkill Valley | W 7-15 |
| Wed, 4/27/2022 | 4:00 PM | vs Tulpehocken | L 3-13 |
| Fri, 4/29/2022 | 6:00 PM | at Fleetwood | L 16-6 |
| Mon, 5/2/2022 | 4:00 PM | vs Kutztown | L 0-18 |
| Wed, 5/4/2022 | 4:00 PM | vs Wyomissing | W 11-10 |
| Mon, 5/9/2022 | 6:30 PM | vs Schuylkill Valley | L 6-13 |
| Tue, 5/10/2022 | 4:15 PM | at Lancaster Mennonite | W 1-17 |
| Wed, 5/11/2022 | 4:00 PM | at Berks Catholic | L 10-0 |
| Mon, 5/23/2022 | 6:00 PM | at Kutztown | L 5-2 |
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