| Date | Time | Opponent | Score |
| Thu, 9/9/2021 | 5:30 PM | at Cumberland Valley | L 16-14 |
| Sat, 9/11/2021 | 1:00 PM | at Villa Maria | W 8-15 |
| Sat, 9/11/2021 | 3:00 PM | at North Allegheny | L 21-13 |
| Sat, 9/11/2021 | 3:00 PM | at Erie McDowell | L 13-12 |
| Tue, 9/14/2021 | 5:30 PM | at Hazleton | W 7-18 |
| Thu, 9/16/2021 | 5:30 PM | vs Central York | W 15-8 |
| Sat, 9/18/2021 | 7:00 PM | vs Pennridge | L 8-9 |
| Sat, 9/18/2021 | 7:00 PM | at North Penn (Lansdale) | L 13-11 |
| Mon, 9/20/2021 | 6:30 PM | at Exeter | W 10-17 |
| Fri, 9/24/2021 | 7:00 PM | vs Perkiomen Valley | W 16-4 |
| Fri, 9/24/2021 | 8:00 PM | vs Erie McDowell | W 12-3 |
| Sat, 9/25/2021 | 7:00 PM | vs Wilson | L 8-9 |
| Sat, 9/25/2021 | 7:00 PM | at Upper Dublin | W 7-12 |
| Mon, 9/27/2021 | 4:00 PM | at Muhlenberg | W 11-12 |
| Wed, 9/29/2021 | 5:30 PM | vs Wilson | W 10-8 |
| Wed, 10/6/2021 | 5:30 PM | vs Cumberland Valley | L 8-16 |
| Sat, 10/9/2021 | 8:00 AM | vs Souderton | W 10-7 |
| Sat, 10/9/2021 | 1:00 PM | vs Upper Dublin | W 11-10 |
| Sat, 10/9/2021 | 6:50 PM | vs Perkiomen Valley | W 17-7 |
| Mon, 10/11/2021 | 5:30 PM | vs Muhlenberg | L 7-8 |
| Wed, 10/13/2021 | 5:00 PM | at Wilson | L 8-4 |
| Mon, 10/18/2021 | 6:00 PM | at Central York | W 3-17 |
| Thu, 10/21/2021 | 5:30 PM | vs Mechanicsburg | W 15-4 |
| Sat, 10/23/2021 | 7:00 PM | vs Upper Dublin | W 14-8 |
| Fri, 10/29/2021 | 7:00 PM | at North Allegheny | L 15-12 |
| Sat, 10/30/2021 | 8:00 AM | vs Wissahickon | L 13-19 |
| Sat, 10/30/2021 | 4:00 PM | at Erie McDowell | W 10-15 |
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