| Date | Time | Opponent | Score |
| Fri, 12/10/2021 | 7:30 PM | vs Conestoga Valley | W 47-40 |
| Sat, 12/11/2021 | 4:00 PM | vs Lebanon | L 29-32 |
| Tue, 12/14/2021 | 6:00 PM | vs Elco | W 39-24 |
| Thu, 12/16/2021 | 6:00 PM | vs Hamburg | W 29-24 |
| Wed, 12/29/2021 | 5:00 PM | at State College | L 59-32 |
| Thu, 12/30/2021 | 10:00 AM | at Bethlehem Catholic | L 58-39 |
| Tue, 1/4/2022 | 7:00 PM | vs Wyomissing | W 49-33 |
| Sat, 1/8/2022 | 12:00 PM | at Daniel Boone | W 24-61 |
| Mon, 1/10/2022 | 6:00 PM | at Schuylkill Valley | L 61-52 |
| Thu, 1/13/2022 | 6:00 PM | vs Oley Valley | L 53-55 |
| Tue, 1/18/2022 | 6:00 PM | at Antietam | W 24-57 |
| Wed, 1/19/2022 | 7:00 PM | at Cocalico | W 28-34 |
| Fri, 1/21/2022 | 6:00 PM | vs Tulpehocken | W 54-21 |
| Mon, 1/24/2022 | 6:00 PM | at Hamburg | W 30-53 |
| Wed, 1/26/2022 | 6:00 PM | at Twin Valley | L 37-28 |
| Fri, 1/28/2022 | 6:00 PM | vs Pequea Valley | W 49-36 |
| Mon, 1/31/2022 | 7:00 PM | at Kutztown | W 37-47 |
| Tue, 2/1/2022 | 6:00 PM | at Wyomissing | L 47-17 |
| Fri, 2/4/2022 | 6:00 PM | vs Brandywine Heights | L 32-50 |
| Mon, 2/7/2022 | 6:00 PM | vs Schuylkill Valley | L 42-50 |
| Wed, 2/9/2022 | 6:00 PM | vs Manheim Central | L 39-45 |
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