| Date | Time | Opponent | Score |
| Fri, 12/10/2021 | 4:00 PM | at Northeastern | L 41-31 |
| Sat, 12/11/2021 | 7:00 PM | at Cocalico | W 32-44 |
| Tue, 12/14/2021 | 5:30 PM | at Blue Mountain | L 57-22 |
| Sat, 12/18/2021 | 12:00 PM | at Wyomissing | L 38-34 |
| Mon, 12/20/2021 | 6:00 PM | at Daniel Boone | W 8-48 |
| Tue, 12/28/2021 | 1:00 PM | vs Lampeter-Strasburg | L 19-38 |
| Tue, 1/4/2022 | 6:00 PM | vs Schuylkill Valley | L 30-51 |
| Wed, 1/5/2022 | 6:00 PM | vs Berks Catholic | L 25-54 |
| Mon, 1/10/2022 | 6:00 PM | vs Muhlenberg | W 40-31 |
| Tue, 1/11/2022 | 6:00 PM | at Twin Valley | L 48-37 |
| Thu, 1/13/2022 | 6:00 PM | at Reading High | L 48-38 |
| Tue, 1/18/2022 | 6:00 PM | vs Wilson | L 27-39 |
| Fri, 1/21/2022 | 6:00 PM | vs Gov. Mifflin | L 26-54 |
| Sat, 1/22/2022 | 2:30 PM | at Tulpehocken | W 32-45 |
| Mon, 1/24/2022 | 6:00 PM | at Muhlenberg | W 25-28 |
| Thu, 1/27/2022 | 6:00 PM | at Exeter | W 37-54 |
| Sat, 1/29/2022 | 12:00 PM | at Pottsville | L 39-27 |
| Mon, 1/31/2022 | 6:00 PM | at Ephrata | L 47-19 |
| Tue, 2/1/2022 | 6:00 PM | vs Daniel Boone | W 46-8 |
| Wed, 2/2/2022 | 6:00 PM | at Elco | L 44-30 |
| Sat, 2/5/2022 | 12:00 PM | at Palmyra | L 37-27 |
| Mon, 2/7/2022 | 6:00 PM | vs Twin Valley | L 30-40 |
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