| Date | Time | Opponent | Score |
| Fri, 12/10/2021 | 4:30 PM | at West York | W 44-52 |
| Sat, 12/11/2021 | 7:00 PM | at Delone Catholic | L 49-36 |
| Tue, 12/14/2021 | 6:00 PM | vs Oley Valley | W 44-30 |
| Thu, 12/16/2021 | 11:00 AM | at Omaha (Neb.) Westside | W 40-45 |
| Fri, 12/17/2021 | 9:30 AM | at Roosevelt (Ore.) | W 12-49 |
| Sat, 12/18/2021 | 9:00 AM | vs Bentonville (AR) | L 33-55 |
| Tue, 12/21/2021 | 6:00 PM | at Gov. Mifflin | W 48-65 |
| Wed, 1/5/2022 | 6:00 PM | at Conrad Weiser | W 25-54 |
| Thu, 1/6/2022 | 6:00 PM | at Exeter | W 30-79 |
| Sat, 1/8/2022 | 9:30 AM | at New Oxford | W 35-45 |
| Mon, 1/10/2022 | 6:00 PM | vs Wilson | W 35-32 |
| Thu, 1/13/2022 | 6:00 PM | at Twin Valley | W 22-37 |
| Sat, 1/15/2022 | 3:30 PM | at York Catholic | W 32-63 |
| Mon, 1/17/2022 | 5:00 PM | vs Garden Spot | W 54-26 |
| Tue, 1/18/2022 | 6:00 PM | vs Daniel Boone | W 46-7 |
| Fri, 1/21/2022 | 6:00 PM | at Muhlenberg | W 29-61 |
| Sat, 1/22/2022 | 1:00 PM | vs Delone Catholic | L 40-55 |
| Tue, 1/25/2022 | 6:00 PM | vs Reading High | W 55-45 |
| Thu, 1/27/2022 | 6:00 PM | vs Gov. Mifflin | W 50-45 |
| Tue, 2/1/2022 | 6:00 PM | at Reading High | W 44-70 |
| Fri, 2/4/2022 | 6:00 PM | vs Exeter | W 68-27 |
| Mon, 2/7/2022 | 6:00 PM | at Wilson | L 38-36 |
| Sat, 2/12/2022 | 2:00 PM | vs Wyomissing | W 52-34 |
| Tue, 2/15/2022 | 8:00 PM | vs Gov. Mifflin | L 40-41 |
| Fri, 2/25/2022 | 7:00 PM | vs Big Spring | W 48-30 |
| Tue, 3/1/2022 | 7:00 PM | vs Bermudian Springs | W 49-46 |
| Sat, 3/5/2022 | 2:30 PM | at Delone Catholic | L 33-27 |
| Thu, 3/10/2022 | 7:00 PM | vs Lake Lehman | L 37-39 |
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