| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at York | L 41-26 |
| Fri, 9/10/2010 | 7:00 PM | at Owen J. Roberts | L 58-6 |
| Fri, 9/17/2010 | 7:00 PM | vs Wilson | L 0-60 |
| Fri, 9/24/2010 | 7:00 PM | vs Exeter | W 19-6 |
| Fri, 10/1/2010 | 7:00 PM | at Gov. Mifflin | L 40-13 |
| Fri, 10/8/2010 | 7:00 PM | vs Daniel Boone | L 33-39 |
| Fri, 10/15/2010 | 7:00 PM | at Conrad Weiser | L 52-14 |
| Fri, 10/22/2010 | 7:00 PM | vs Pottsville | L 21-29 |
| Fri, 10/29/2010 | 7:00 PM | vs Twin Valley | W 31-15 |
| Fri, 11/5/2010 | 7:00 PM | at Muhlenberg | L 35-28 |
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