| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | vs Ephrata | W 35-7 |
| Fri, 9/10/2010 | 7:00 PM | at Blue Mountain | L 28-6 |
| Fri, 9/17/2010 | 7:00 PM | vs Holy Name | W 48-12 |
| Fri, 9/24/2010 | 7:00 PM | at Reading High | L 19-6 |
| Fri, 10/1/2010 | 7:00 PM | vs Muhlenberg | W 33-9 |
| Fri, 10/8/2010 | 7:00 PM | at Twin Valley | W 20-35 |
| Fri, 10/15/2010 | 7:00 PM | vs Pottsville | L 17-34 |
| Fri, 10/22/2010 | 7:00 PM | at Conrad Weiser | L 47-21 |
| Fri, 10/29/2010 | 7:00 PM | vs Gov. Mifflin | L 7-37 |
| Fri, 11/5/2010 | 7:00 PM | at Daniel Boone | L 21-10 |
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