| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at Pottsville | L 28-25 |
| Sat, 9/11/2010 | 1:00 PM | vs Marion Center | W 38-14 |
| Fri, 9/17/2010 | 7:00 PM | at Muhlenberg | W 6-31 |
| Fri, 9/24/2010 | 7:00 PM | at Kutztown | W 14-49 |
| Sat, 10/2/2010 | 1:30 PM | vs Fleetwood | W 49-7 |
| Fri, 10/8/2010 | 7:00 PM | at Hamburg | W 20-37 |
| Sat, 10/16/2010 | 1:30 PM | vs Schuylkill Valley | W 41-31 |
| Sat, 10/23/2010 | 1:30 PM | vs Holy Name | L 14-36 |
| Fri, 10/29/2010 | 7:00 PM | at Central Catholic | W 14-35 |
| Sat, 11/6/2010 | 1:30 PM | vs Blue Mountain | L 20-42 |
| Fri, 11/12/2010 | 7:00 PM | at Delone Catholic | W 21-28 |
| Fri, 11/19/2010 | 7:00 PM | at Lancaster Catholic | W 14-21 |
| Fri, 11/26/2010 | 7:00 PM | at Trinity | L 28-0 |
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