| Date | Time | Opponent | Score |
| Fri, 9/3/2010 | 7:00 PM | at James Buchanan | W 20-46 |
| Fri, 9/10/2010 | 7:00 PM | vs Jim Thorpe | L 7-34 |
| Fri, 9/17/2010 | 7:00 PM | at Upper Dauphin | W 12-49 |
| Fri, 9/24/2010 | 7:00 PM | at Fleetwood | W 7-37 |
| Sat, 10/2/2010 | 7:00 PM | vs Kutztown | W 33-28 |
| Fri, 10/8/2010 | 7:00 PM | at Schuylkill Valley | L 36-7 |
| Fri, 10/15/2010 | 7:00 PM | vs Hamburg | L 21-28 |
| Fri, 10/22/2010 | 7:00 PM | at Blue Mountain | L 51-7 |
| Fri, 10/29/2010 | 7:00 PM | vs Wyomissing | L 14-35 |
| Fri, 11/5/2010 | 7:00 PM | vs Holy Name | L 21-41 |
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