| Date | Time | Opponent | Score |
| Fri, 8/27/2021 | 7:00 PM | at Shenandoah Valley | W 14-27 |
| Fri, 9/3/2021 | 7:00 PM | vs Nativity | L 24-46 |
| Fri, 9/10/2021 | 7:00 PM | at Pequea Valley | W 37-76 |
| Fri, 9/17/2021 | 7:00 PM | vs Twin Valley | L 22-68 |
| Fri, 9/24/2021 | 7:00 PM | at Schuylkill Valley | L 28-8 |
| Fri, 10/1/2021 | 7:00 PM | vs Hamburg | L 34-47 |
| Fri, 10/8/2021 | 7:00 PM | vs Susquehannock | L 18-49 |
| Fri, 10/15/2021 | 7:00 PM | vs Wyomissing | L 6-56 |
| Fri, 10/22/2021 | 7:00 PM | at Conrad Weiser | L 62-30 |
| Fri, 10/29/2021 | 7:00 PM | at Fleetwood | L 49-30 |
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