| Date | Time | Opponent | Score |
| Sat, 9/4/2010 | 1:00 PM | at Octorara | L 35-19 |
| Fri, 9/10/2010 | 7:00 PM | vs Donegal | L 13-21 |
| Fri, 9/17/2010 | 7:00 PM | at Annville-Cleona | L 68-34 |
| Fri, 9/24/2010 | 7:00 PM | vs Central Catholic | L 7-37 |
| Sat, 10/2/2010 | 1:30 PM | at Wyomissing | L 49-7 |
| Sat, 10/9/2010 | 7:00 PM | vs Holy Name | L 2-40 |
| Fri, 10/15/2010 | 7:00 PM | at Blue Mountain | L 56-21 |
| Fri, 10/22/2010 | 7:00 PM | vs Hamburg | L 7-49 |
| Fri, 10/29/2010 | 7:00 PM | at Schuylkill Valley | L 42-0 |
| Fri, 11/5/2010 | 7:00 PM | vs Kutztown | W 54-14 |
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