| Date | Time | Opponent | Score |
| Fri, 12/10/2021 | 6:00 PM | vs Loyalsock | W 50-44 |
| Sat, 12/11/2021 | 4:30 PM | at Lancaster Catholic | W 47-56 |
| Mon, 12/13/2021 | 6:00 PM | at Pottsville | W 46-49 |
| Fri, 12/17/2021 | 6:00 PM | vs Conrad Weiser | W 59-45 |
| Tue, 12/21/2021 | 6:00 PM | vs Gov. Mifflin | W 72-70 |
| Wed, 12/22/2021 | 6:00 PM | at Lancaster Mennonite | W 57-68 |
| Mon, 1/3/2022 | 6:00 PM | at Reading High | L 67-51 |
| Thu, 1/6/2022 | 6:00 PM | at Exeter | W 51-56 |
| Sat, 1/8/2022 | 11:00 AM | vs Abington Heights | W 50-41 |
| Tue, 1/11/2022 | 6:00 PM | at Wilson | L 51-48 |
| Wed, 1/12/2022 | 6:00 PM | vs Nativity | W 62-49 |
| Fri, 1/14/2022 | 6:00 PM | vs Twin Valley | W 61-43 |
| Sat, 1/15/2022 | 7:00 PM | at Trinity | W 54-61 |
| Mon, 1/17/2022 | 6:00 PM | at Daniel Boone | W 26-80 |
| Thu, 1/20/2022 | 6:00 PM | vs Muhlenberg | W 80-64 |
| Wed, 1/26/2022 | 6:00 PM | at York Catholic | W 52-69 |
| Fri, 1/28/2022 | 6:00 PM | at Gov. Mifflin | W 43-53 |
| Mon, 1/31/2022 | 7:00 PM | vs Reading High | L 70-87 |
| Thu, 2/3/2022 | 6:00 PM | vs Exeter | W 60-40 |
| Tue, 2/8/2022 | 6:00 PM | vs Wilson | W 56-43 |
| Thu, 2/10/2022 | 6:00 PM | at Holy Ghost Prep | W 43-67 |
| Mon, 2/14/2022 | 7:00 PM | vs Antietam | W 66-52 |
| Wed, 2/16/2022 | 6:00 PM | vs Exeter | W 41-40 |
| Fri, 2/18/2022 | 8:00 PM | at Reading High | L 51-35 |
| Thu, 2/24/2022 | 7:00 PM | vs Elco | W 55-40 |
| Mon, 2/28/2022 | 7:00 PM | vs Littlestown | W 58-46 |
| Thu, 3/3/2022 | 4:15 PM | vs Middletown | W 60-37 |
| Tue, 3/8/2022 | 7:00 PM | vs Archbishop Carroll | L 61-68 |
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