| Date | Time | Opponent | Score |
| Fri, 12/10/2021 | 7:00 PM | vs Upper Perkiomen | W 52-44 |
| Sat, 12/11/2021 | 6:00 PM | vs Pequea Valley | W 60-31 |
| Tue, 12/14/2021 | 5:30 PM | at Hamburg | W 50-78 |
| Fri, 12/17/2021 | 6:00 PM | at Oley Valley | W 51-62 |
| Tue, 12/21/2021 | 6:00 PM | at Wyomissing | L 47-33 |
| Tue, 12/28/2021 | 6:00 PM | at Annville-Cleona | W 47-69 |
| Wed, 12/29/2021 | 3:00 PM | at Northern Lebanon | W 34-42 |
| Tue, 1/4/2022 | 6:00 PM | vs Kutztown | W 46-36 |
| Thu, 1/6/2022 | 7:30 PM | at Antietam | L 50-48 |
| Sat, 1/8/2022 | 3:00 PM | at Greenwood | W 55-66 |
| Tue, 1/11/2022 | 6:00 PM | vs Brandywine Heights | W 46-34 |
| Fri, 1/14/2022 | 6:00 PM | at Schuylkill Valley | W 44-55 |
| Sat, 1/22/2022 | 1:00 PM | vs Conrad Weiser | L 50-64 |
| Tue, 1/25/2022 | 6:00 PM | at Brandywine Heights | W 59-60 |
| Wed, 1/26/2022 | 6:00 PM | at Pequea Valley | W 39-64 |
| Sat, 1/29/2022 | 5:30 PM | vs Fleetwood | W 59-51 |
| Mon, 1/31/2022 | 6:00 PM | vs Hamburg | W 65-51 |
| Wed, 2/2/2022 | 6:00 PM | vs Oley Valley | W 54-45 |
| Thu, 2/3/2022 | 4:30 PM | at Kutztown | L 71-60 |
| Sat, 2/5/2022 | 6:00 PM | at Upper Dauphin | W 39-73 |
| Tue, 2/8/2022 | 7:30 PM | vs Antietam | L 44-61 |
| Fri, 2/11/2022 | 7:30 PM | vs Veritas Academy | W 58-23 |
| Mon, 2/21/2022 | 7:00 PM | vs Brandywine Heights | W 48-44 |
| Thu, 2/24/2022 | 7:00 PM | at York Catholic | L 61-58 |
| Mon, 2/28/2022 | 7:00 PM | vs Lancaster Catholic | W 72-51 |
| Wed, 3/9/2022 | 7:30 PM | at West Catholic High School | L 69-32 |
|